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Important GLP1 Update

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Important information for Billingshurst patients on HRT, Contraceptive pills or planning to conceive and taking GLP1 medications including Mounjaro (Tirzepatide) and WeGovey(Semaglutide).

We’d like to share with your 2 important updates from the Faculty of Sexual and Reproductive Health and the British Menopause Society which may affect some of our patients.

As we are not always notified if a patient accesses these medications privately or online we are sending this information to all female patients to ensure all who may be affected are aware of these updates.

HRT

If you are on HRT and you take a Progesterone tablet such as Utrogestan, micronised progesterone, Norethisterone, Medroxyprogesterone or your HRT is an oral combined tablet then please note:

 Mounjaro (Tirzepatide) and Semaglutide (Wegovey or Ozempic) injections may reduce the absorption of oral progesterone, especially when starting the Injection or increasing the dose. This could lead to unexpected bleeding or thickening of the womb lining.

To stay safe you may need a higher dose of Progesterone for 4 weeks after starting or increasing Tirzepatide/Semaglutide. Please therefore contact the surgery for a review.

Alternatively you may like to consider switching to a non oral version such as the Mirena coil or combined patch to overcome this issue. At your review your GP can help you to decide the most suitable option for your needs.

 

If you experience any unscheduled/unexpected vaginal bleeding on your HRT you must urgently seek medical advice.

Oral contraceptive pill

If you are taking an oral contraceptive pill, again these medications may affect it's effectiveness. The patient information leaflet provided by The Faculty of Sexual & Reproductive Healthcare.  below provides further Information on this but It Is recommended to use an additional barrier method of contraception (condoms) for 4 weeks after starting or changing your dose.

Trying to conceive

Depending on the GLP1 Injection you are taking it is advised that you stop taking the Injection 1-3 months prior to conceiving. Further Information is available via the patient information leaflet provided by The Faculty of Sexual & Reproductive Healthcare. 


Page last updated or reviewed: June 2025